Tumor resistance to chemotherapy represents an important challenge in modern oncology. Although platinum (Pt)-based drugs have demonstrated excellent therapeutic potential, their effectiveness in a wide range of tumors is limited by the development of resistance mechanisms. One of these mechanisms includes increased cisplatin sequestration/efflux by the copper-transporting ATPase, ATP7B. However, targeting ATP7B to reduce Pt tolerance in tumors could represent a serious risk because suppression of ATP7B might compromise copper homeostasis, as happens in Wilson disease.

TEOBResumS and SEOBNRv4 are the two existing semianalytical gravitational waveform models for spin-aligned coalescing black hole binaries based on the effective-one-body (EOB) approach. They are informed by numerical relativity simulations and provide the relative dynamics and waveforms from early inspiral to plunge, merger, and ringdown. The central building block of each model is the EOB resummed Hamiltonian. The two models implement different Hamiltonians that are both deformations of the Hamiltonian of a test spinning black hole moving around a Kerr black hole.

We consider an empirical Bayes approach to standard nonparametric regression estimation using a nonlinear wavelet methodology. Instead of specifying a single prior distribution on the parameter space of wavelet coefficients, which is usually the case in the existing literature, we elicit the epsilon-contamination class of prior distributions that is particularly attractive to work with when one seeks robust priors in Bayesian analysis.

Sparse solvers are one of the building blocks of any technology for reliable and high-performance scientific and engineering computing. In this paper we present a software package which implements an efficient multigrid sparse solver running on Graphics Processing Units. The package is a branch of a wider initiative of software development for sparse Linear Algebra computations on emergent HPC architectures involving a large research group working in many application projects over the last ten years.

We consider a simple example of a partially dissipative hyperbolic system violating the Shizuta-Kawashima condition, ie such that some eigendirections do not exhibit dissipation at all. In the space-time resonances framework introduced by Germain, Masmoudi and Shatah, we prove that, when the source term has a Nonresonant Bilinear Form, as proposed by Pusateri and Shatah CPAM 2013, the formation of singularities is prevented, despite the lack of dissipation. This allows us to show that smooth solutions to this preliminary case-study model exist globally in time.

In this paper, we discuss the convergence of an Algebraic MultiGrid (AMG) method for general symmetric positive-definite matrices. The method relies on an aggregation algorithm, named coarsening based on compatible weighted matching, which exploits the interplay between the principle of compatible relaxation and the maximum product matching in undirected weighted graphs.