Background: Mutations of the mitochondrial protein paraplegin cause hereditary spastic paraplegia type 7 (SPG7), a so-far untreatable degenerative disease of the upper motoneuron with still undefined pathomechanism. The intermittent mitochondrial permeability transition pore (mPTP) opening, called flickering, is an essential process that operates to maintain mitochondrial homeostasis by reducing intra-matrix Ca and reactive oxygen species (ROS) concentration, and is critical for efficient synaptic function.

The post-Minkowskian approach to gravitationally interacting binary systems (i.e., perturbation theory in G, without assuming small velocities) is extended to the computation of the dynamical effects induced by the tidal deformations of two extended bodies, such as neutron stars. Our derivation applies general properties of perturbed actions to the effective field theory description of tidally interacting bodies. We compute several tidal invariants (notably the integrated quadrupolar and octupolar actions) at the fast post-Minkowskian order.

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We consider an empirical Bayes approach to standard nonparametric regression estimation using a nonlinear wavelet methodology. Instead of specifying a single prior distribution on the parameter space of wavelet coefficients, which is usually the case in the existing literature, we elicit the epsilon-contamination class of prior distributions that is particularly attractive to work with when one seeks robust priors in Bayesian analysis.

Timelike geodesics on a hyperplane orthogonal to the symmetry axis of the Godel spacetime appear to be elliptic-like if standard coordinates naturally adapted to the cylindrical symmetry are used. The orbit can then be suitably described through an eccentricity-semi-latus rectum parametrization, familiar from the Newtonian dynamics of a two-body system. However, changing coordinates such planar geodesics all become explicitly circular, as exhibited by Kundt's form of the Godel metric.

We investigate nonlinear elliptic Dirichlet problems whose growth is driven by a general anisotropic N-function, which is not necessarily of power-type and need not satisfy the $\Delta_2$ nor the $\nabla_2$ -condition. Fully anisotropic, non-reflexive Orlicz-Sobolev spaces provide a natural functional framework associated with these problems. Minimal integrability assumptions are detected on the datum on the right-hand side of the equation ensuring existence and uniqueness of weak solutions.

WeinvestigatethelinearstabilityofshearsneartheCouetteflowforaclassof2Dincompressible stably stratified fluids. Our main result consists of nearly optimal decay rates for perturbations of stationary states whose velocities are monotone shear flows (U (y), 0) and have an exponential density profile. In the case of the Couette flow U(y) = y, we recover the rates predicted by Hartman in 1975, by adopting an explicit point-wise approach in frequency space. As a by-product, this implies optimal decay rates as well as Lyapunov instability in L2 for the vorticity.

We investigate the motion of uncharged particles scattered by a binary system consisting of extremely charged black holes in equilibrium as described by the Majumdar-Papapetrou solution. We focus on unbound orbits confined to the plane containing both black holes. We consider the two complementary situations of particles approaching the system along a direction parallel to the axis where the black holes are displaced and orthogonal to it.