We report a coarse-grained molecular dynamics simulation study of a bundle of parallel actin filaments under supercritical conditions pressing against a loaded mobile wall using a particle-based approach where each particle represents an actin unit. The filaments are grafted to a fixed wall at one end and are reactive at the other end, where they can perform single monomer (de) polymerization steps and push on a mobile obstacle.

The large amount of work on community detection and its applications leaves unaddressed one important question: the statistical validation of the results. We present a methodology able to clearly detect the truly significance of the communities identified by some technique, permitting us to discard those that could be merely the consequence of edge positions in the network. Given a community detection method and a network of interest, our procedure examines the stability of the partition recovered against random perturbations of the original graph structure.

Estimates for solutions to homogeneous Dirichlet problems for a class of elliptic equations with zero order term in the form L(u) = g(x, u) + f (x),where the operator L fulfills an anisotropic elliptic condition, are established. Such estimates are obtained in terms of solutions to suitable problems with radially symmetric data, when no sign conditions on g are required.

By means of mesoscopic numerical simulations of a model soft-glassy material, we investigate the role of boundary roughness on the flow behaviour of the material, probing the bulk/wall and global/local rheologies. We show that the roughness reduces the wall slip induced by wettability properties and acts as a source of fluidisation for the material. A direct inspection of the plastic events suggests that their rate of occurrence grows with the fluidity field, reconciling our simulations with kinetic elasto-plastic descriptions of jammed materials.

We present the latest version of OpenCAPWAP, our open-source implementation of the Internet Engineering Task Force control and provisioning of wireless access point (CAPWAP) protocol. The CAPWAP protocol is designed to support centralized management of large-scale and heterogeneous wireless networks, with a special focus on IEEE 802.11-based networks. The implementation presented in this paper improves substantially on the previous version, adding full support for the Split MAC architecture and decoupling completely the implementation from a specific driver solution.

Gene expression data from high-throughput assays, such as microarray, are often used to predict cancer survival. However, available datasets consist of a small number of samples (n patients) and a large number of gene expression data (p predictors). Therefore, the main challenge is to cope with the high-dimensionality. Moreover, genes are co-regulated and their expression levels are expected to be highly correlated. In order to face these two issues, network based approaches have been proposed.

In the present paper, we constructed an estimator of a delta contaminated mixing density function $g(\lam)$ of an intensity $\lambda$ of the Poisson distribution. The estimator is based on an expansion of the continuous portion $g_0(\lambda)$ of the unknown pdf over an overcomplete dictionary with the recovery of the coefficients obtained as the solution of an optimization problem with Lasso penalty.

The scattering of massive particles by a Schwarzschild black hole also undergoing a drag force is considered. The latter is modeled as a viscous force acting on the orbital plane, with components proportional to the associated particle 4-velocity components. The energy and angular momentum losses as well as the dependence of the hyperbolic scattering angle on the strength of the drag are investigated in situations where strong field effects cause large deflections.

Objectives Identifying the predictive factors of Sustained Virological Response (SVR) represents an important challenge in new interferon-based DAA therapies. Here, we analyzed the kinetics of antiviral response associated with a triple drug regimen, and the association between negative residual viral load at different time points during treatment. Methods Twenty-three HCV genotype 1 (GT 1a n = 11; GT1b n = 12) infected patients were included in the study.