The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans

Immunosenescence is thought to result from cellular aging and to reflect exposure to environmental stressors and antigens, including cytomegalovirus (CMV). However, not all of the features of immunosenescence are consistent with this view, and this has led to the emergence of the sister theory of "inflammaging". The recently discovered diffuse tissue distribution of resident memory T cells (TRM) which don't recirculate, calls these theories into question. These cells account for most T cells residing in barrier epithelia which sit in and travel through the extracellular matrix (ECM).

Late-time evolution of cosmological models with fluids obeying a Shan-Chen-like equation of state

Classical as well as quantum features of the late-time evolution of cosmological models with fluids obeying a Shan-Chen-like equation of state are studied. The latter is of the type p=weff(?)? and has been used in previous works to describe, e.g., a possible scenario for the growth of the dark-energy content of the present Universe. At the classical level, the fluid dynamics in a spatially flat Friedmann-Robertson-Walker background implies the existence of two possible equilibrium solutions depending on the model parameters associated with (asymptotic) finite pressure and energy density.

A sufficient condition for the stability of direct quadrature methods for Volterra integral equations

Within the theoretical framework of the numerical stability analysis for the Volterra integral equations, we consider a new class of test problems and we study the long-time behavior of the numerical solution obtained by direct quadrature methods as a function of the stepsize. Furthermore, we analyze how the numerical solution responds to certain perturbations in the kernel.

Multitemporal Backscattering Logistic Analysis for Intertidal Bathymetry

A new methodology for the mapping of intertidal terrain morphology is presented. It is based on the use of synthetic aperture radar (SAR) images and the temporal correlation between the SAR backscatter intensity and the water level on the intertidal zone. The proposed methodology does not require manual editing, providing a set of geolocated pixels that can be used to generate a digital elevation model of the intertidal zone. The methodology is validated using TerraSAR-X SAR images acquired over Tagus estuary.

New gravitational self-force analytical results for eccentric orbits around a Schwarzschild black hole

We raise the analytical knowledge of the eccentricity expansion of the Detweiler-Barack-Sago redshift invariant in a Schwarzschild spacetime up to the 9.5th post-Newtonian order (included) for the e(2) and e(4) contributions, and up to the 4th post-Newtonian order for the higher eccentricity contributions through e(20). We convert this information into an analytical knowledge of the effective-one-body radial potentials (d) over bar (u), p(u) and q(u) through the 9.5th post-Newtonian order. We find that our analytical results are compatible with current corresponding numerical self-force data.

Nonlocal gravity: Conformally flat spacetimes

The field equations of the recent nonlocal generalization of Einstein's theory of gravitation are presented in a form that is reminiscent of general relativity. The implications of the nonlocal field equations are studied in the case of conformally flat spacetimes. Even in this simple case, the field equations are intractable. Therefore, to gain insight into the nature of these equations, we investigate the structure of nonlocal gravity (NLG) in 2D spacetimes.

Confirming and improving post-Newtonian and effective-one-body results from self-force computations along eccentric orbits around a Schwarzschild bh

We analytically compute, through the six-and-a-half post-Newtonian order, the second-order-in-eccentricity piece of the Detweiler-Barack-Sago gauge-invariant redshift function for a small mass in eccentric orbit around a Schwarzschild black hole. Using the first law of mechanics for eccentric orbits [A. Le Tiec, First law of mechanics for compact binaries on eccentric orbits, Phys. Rev. D 92, 084021 (2015).] we transcribe our result into a correspondingly accurate knowledge of the second radial potential of the effective-one-body formalism [A. Buonanno and T.

Three-Dimensional Variational Assimilation of InSAR PWV Using the WRFDA Model

This paper studies the problem of the assimilation of precipitable water vapor (PWV), estimated by synthetic aperture radar interferometry, using the Weather Research and Forecast Data Assimilation model 3-D variational data assimilation system. The experiment is designed to assess the impact of the PWV assimilation on the hydrometers and the rainfall predictions during 12 h after the assimilation time. A methodology to obtain calibrated maps of PWV and estimated their precision is also presented.