The development of high-efficiency porous catalyst membranes critically depends on our understanding of where the majority of the chemical conversions occur within the porous structure. This requires mapping of chemical reactions and mass transport inside the complex nanoscale architecture of porous catalyst membranes which is a multiscale problem in both the temporal and spatial domains.

Robust Design Optimization (RDO) represents a really interesting opportunity when the specifications of the design are careful and accurate: the possibility to optimize an industrial object for the real usage situation, improving the overall performances while reducing the risk of occurrence of off-design con- ditions, strictly depends on the availability of the information about the probability of occurrence of the various operative conditions during the lifetime of the design.

The human retina is a specialized tissue involved in light stimulus transduction. Despite its unique biology, an accurate reference transcriptome is still missing. Here, we performed gene expression analysis (RNA-seq) of 50 retinal samples from non-visually impaired post-mortem donors. We identified novel transcripts with high confidence (Observed Transcriptome (ObsT)) and quantified the expression level of known transcripts (Reference Transcriptome (RefT)). The ObsT included 77 623 transcripts (23 960 genes) covering 137 Mb (35 Mb new transcribed genome).

International initiatives such as the Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) are collecting multiple datasets at different genome-scales with the aim of identifying novel cancer biomarkers and predicting survival of patients. To analyze such data, several statistical methods have been applied, among them Cox regression models. Although these models provide a good statistical framework to analyze omic data, there is still a lack of studies that illustrate advantages and drawbacks in integrating biological information and selecting groups of biomarkers.

In this talk, first, we review the concept of gene-environmental interaction on the light of emerging results and the use of modern high-throughput technologies; we illustrate its impact on the understanding of complex human diseases. Then, we provide an overview of the methods available to process NGS data with particular emphasis to the detection of genomic variants, the analysis of epigenomic and transcriptional data produced by modern sequencers. Finally, we discuss how multiomic data can be used to improve our way of studying complex diseases and can provide novel research perspectives.

Free-living bacteria grown under aerobic conditions were used to investigate, by next-generation RNA sequencing analysis, the transcriptional profiles of Sinorhizobium meliloti wild-type 1021 and its derivative, RD64, overproducing the main auxin indole-3-acetic acid (IAA). Among the upregulated genes in RD64 cells, we detected the main nitrogen-fixation regulator fixJ, the two intermediate regulators fixK and nifA, and several other genes known to be FixJ targets.

Nell'ambito del workshop d'inaugurazione dell'anno accademico dell'Associazione Matematica & Realta', la presentazione intende offrire alla platea degli insegnanti di matematica delle scuole superiori di secondo grado un esempio realmente implementato di attivita' di studio e ricerca di matematica applicata. Vi si trovano ben delineati i passi fondamentali che conducono dal problema reale alla soluzione numerica proposta, manifestando la necessita' di conoscenze interdisciplinari per giungere all' uso critico ed efficace dello strumento matematico.

Neglecting the horizontal variability of the atmosphere in the forward model for the simulation of limb emission radiances causes a systematic error in MIPAS retrieved profiles. The horizontal gradient model will be introduced into the Optimized Retrieval Model (ORM) v8, which will be used for the final ESA reprocessing of the whole mission. Several optimizations exploiting the spherical symmetry of the atmosphere can no longer be used. Therefore, both the ray tracing and the radiative transfer integration algorithms have been completely rewritten.