This contribution outlines current research aimed at developing models for personalized type 2 diabetes mellitus (T2D) prevention in the framework of the European project PRAESIIDIUM (Physics Informed Machine Learn-ing-Based Prediction and Reversion of Impaired Fasting Glucose Management) aimed at building a digital twin for preventing T2D in patients at risk.

We investigate the long-time properties of the two-dimensional inviscid Boussinesq equations near a stably stratified Couette flow, for an initial Gevrey perturbation of size ?. Under the classical Miles-Howard stability condition on the Richardson number, we prove that the system experiences a shear-buoyancy instability: the density variation and velocity undergo an O(t-1/2) inviscid damping while the vorticity and density gradient grow as O(t1/2). The result holds at least until the natural, nonlinear timescale t??-2.

Preservation of the angle of reflection when an internal gravity wave hits a sloping boundary generates a focusing mechanism if the angle between the direction of propagation of the incident wave and the horizontal is close to the slope inclination (near-critical reflection). This paper provides an explicit description of the leading approximation of the unique Leray solution to the near-critical reflection of internal waves from a slope in the form of a beam wave.

We prove the nonlinear asymptotic stability of stably stratified solutions to the Incompressible Porous Media equation (IPM) for initial perturbations in ?H1- (R2) ? ?H s(R2) with s > 3 and for any 0 < < 1. Such result improves the existing literature, where the asymptotic stability is proved for initial perturbations belonging at least to H20(R2). More precisely, the aim of the article is threefold. First, we provide a simplified and improved proof of global-in-time well-posedness of the Boussinesq equations with strongly damped vorticity in H1- (R2)?