3D printers based on the additive manufacturing technology create objects layer-by-layer dropping fused material. As a consequence, strong overhangs cannot be printed because the new-come material does not find a suitable support over the last deposed layer. In these cases, one can add support structures (scaffolds) which make the object printable, to be removed at the end. In this paper, we propose a level set based method to create object-dependent support structures, specifically conceived to reduce both the amount of additional material and the printing time.

Infection by Leishmania protozoan parasites can cause a variety of disease outcomes in humans and other mammals, from single self-healing cutaneous lesions to a visceral dissemination of the parasite. The correlation between chronic lesions and ecto-nucleotidase enzymes activity on the surface of the parasite is addressed here using damage caused in epithelial cells by nitric oxide.

The problem is addressed of the maximal integrability of the gradient of solutions to quasilinear elliptic equations, with merely measurable coefficients, in two variables. Optimal results are obtained in the framework of Orlicz spaces, and in the more general setting of all rearrangement-invariant spaces. Applications to special instances are exhibited, which provide new gradient bounds, or improve certain results available in the literature.

A comprehensive approach to Sobolev-type embeddings, involving arbitrary rearrangement- invariant norms on the entire Euclidean space R^n, is offered. In particular, the optimal target space in any such embedding is exhibited.

A comprehensive approach to Sobolev-type embeddings, involving arbitrary rearrangement- invariant norms on the entire Euclidean space R^n, is offered. In particular, the optimal target space in any such embedding is exhibited.

A model consisting of a kinetic equation for \run-and-tumble" biased bacteria motion, coupled with two reaction-diusion equations for chemical signals, is studied. It displays time- asymptotic propagation at constant velocity, i.e., aggregated travelling (exponential) layers. To capture them for various parameters, a well-balanced setup is based on both \Case's elementary solutions" and L-spline reconstruction. Far from the diusive regime, waves travelling at dierent velocities (bistability) are proved to coexist.

A Leaky Integrate-and-Fire (LIF) model with stochastic current-based linkages is considered to describe the firing activity of neurons interacting in a (2. ×. 2)-size feed-forward network. In the subthreshold regime and under the assumption that no more than one spike is exchanged between coupled neurons, the stochastic evolution of the neuronal membrane voltage is subject to random jumps due to interactions in the network. Linked Gauss-Diffusion processes are proposed to describe this dynamics and to provide estimates of the firing probability density of each neuron.

The topic of controlled drug release has received much attention in recent years, for example in the design of tablets and in local drug delivery devices such as stents, transdermal patches, therapeutic contact lenses and orthopaedic implants. In recent years, we have developed a series of models for such devices to describe drug release from a polymeric platform, drug transport in surrounding biological tissues and fully coupled models of them.

In this paper we describe a theoretical mathematical model of dual drug delivery from a durable polymer coated medical device. We demonstrate how the release rate of each drug may in principle be controlled by altering the initial loading configuration of the two drugs. By varying the underlying microstructure of polymer coating, further control may be obtained, providing the opportunity to tailor the release profile of each drug for the given application.