Controlled drug delivery from a multilayer spherical capsule is used for several therapeutic applications. Developing a theoretical understanding of mass transfer in the multilayer capsule is critical for understanding and optimizing targeted drug delivery. This paper presents an analytical solution for the mass transport problem in a general multilayer sphere involving diffusion as well as drug immobilization in various layers due to binding reactions.

A prodromal phase of Parkinson's disease (PD) may precede motor manifestations by decades. PD patients' siblings are at higher risk for PD, but the prevalence and distribution of prodromal symptoms are unknown. The study objectives were (1) to assess motor and non-motor features estimating prodromal PD probability in PD siblings recruited within the European PROPAG-AGEING project; (2) to compare motor and non-motor symptoms to the well-established DeNoPa cohort.

Terrestrial and marine ecosystems provide essential goods and services to human societies. In the last decades, however, anthropogenic pressure has produced a loss of ecosystem services that can seriously affect human wellbeing and climate processes at local and regional scale.

Edge and Fog Computing will be increasingly pervasive in the years to come due to the benefits they bring in many specific use-case scenarios over traditional Cloud Computing. Nevertheless, the security concerns Fog and Edge Computing bring in have not been fully considered and addressed so far, especially when considering the underlying technologies (e.g. virtualization) instrumental to reap the benefits of the adoption of the Edge paradigm. In particular, these virtualization technologies (i.e.

We numerically study the dynamics of a polydisperse double emulsion under a symmetric shear flow. We show that both dispersity and shear rate crucially affect the behavior of the innermost drops and of the surrounding shell.

This article is concerned with the analysis of the one-dimensional compressible Euler equations with a singular pressure law, the so-called hard sphere equation of state. The result is twofold. First, we establish the existence of bounded weak solutions by means of a viscous regularization and refined compensated compactness arguments. Second, we investigate the smooth setting by providing a de- tailed description of the impact of the singular pressure on the breakdown of the solutions.

Chandipura vesiculovirus (CHPV) is a rapidly emerging pathogen responsible for causing acute encephalitis. Due to its widespread occurrence in Asian and African countries, this has become a global threat, and there is an urgent need to design an effective and nonallergenic vaccine against this pathogen. The present study aimed to develop a multi-epitope vaccine using an immunoinformatics approach. The conventional method of vaccine design involves large proteins or whole organism which leads to unnecessary antigenic load with increased chances of allergenic reactions.

To achieve high performance and high energy efficiency on near-future exascale computing systems, three key technology gaps needs to be bridged. These gaps include: energy efficiency and thermal control; extreme computation efficiency via HW acceleration and new arithmetics; methods and tools for seamless integration of reconfigurable accelerators in heterogeneous HPC multi-node platforms.

In this article, we deal with the model selection problem for estimating a Gaussian Graphical Model (GGM) by regression based techniques. In fact, although regression based techniques are well understood and have good theoretical properties, it is still not clear which criterion is more appropriate for model selection. In this work we do a comparative study between CV and BIC, obtaining important conclusions that can be of practical interest in different contexts of data analysis.

A recently introduced approach to the classical gravitational dynamics of binary systems involves intricate integrals (linked to a combination of nonlocal-in-time interactions with iterated 1r-potential scattering) which have so far resisted attempts at their analytical evaluation.