We numerically study the dynamics of a polydisperse double emulsion under a symmetric shear flow. We show that both dispersity and shear rate crucially affect the behavior of the innermost drops and of the surrounding shell.

We provide a brief survey of our current developments in the simulation-based design of novel families of mesoscale porous materials using computational kinetic theory. Prospective applications on exascale computers are also briefly discussed and commented on, with reference to two specific examples of soft mesoscale materials: microfluid crystals and bi-continuous jels.

One of the most distinctive hallmarks of many-body systems far from equilibrium is the spontaneous emergence of order under conditions where disorder would be plausibly expected. Here, we report on the self-transition between ordered and disordered emulsions in divergent microfluidic channels, i.e., from monodisperse assemblies to heterogeneous polydisperse foamlike structures, and back again to ordered ones.

We establish versions for fractional Orlicz-Sobolev seminorms, built upon Young functions, of the Bourgain-Brezis-Mironescu theorem on the limit as s ->1^-, and of the Maz'ya-Shaposhnikova theorem on the limit as s->0^-, dealing with classical fractional Sobolev spaces. As regards the limit as s ->1^-, Young functions with an asymptotic linear growth are also considered in connection with the space of functions of bounded variation. Concerning the limit as s->0^+, Young functions fulfilling the \Delta_2-condition are admissible.

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The non-equilibrium structural and dynamical properties of semiflexible polymers confined to two dimensions under oscillatory shear flow are investigated by Brownian multi-particle collision dynamics. Two different scenarios will be considered: Filaments with both fixed ends [1] and wall-anchored chains [2].The results of the numerical studies will be presented and discussed. 1] A. Lamura, R. G. Winkler, 'Tethered semiflexible polymer under large amplitude oscillatory shear', Polymers 11, 737 (2019) [2] A. Lamura, R. G. Winkler, G.

The present work is motivated by the development of a mathematical model mimicking the mechanisms observed in lab-on-chip experiments, made to reproduce on microfluidic chips the in vivo reality. Here we consider the Cancer-on-Chip experiment where tumor cells are treated with chemotherapy drug and secrete chemical signals in the environment attracting multiple immune cell species. The in silico model here proposed goes towards the construction of a "digital twin" of the experimental immune cells in the chip environment to better understand the complex mechanisms of immunosurveillance.

Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo in which OCRL plays a key part. We identify mitochondrial DNA and TLR9 as the cargo and the receptor that triggers and mediates, respectively, this response.

We numerically study the dynamic behavior under a symmetric shear flow of selected examples of concentrated phase emulsions with multicore morphology confined within a microfluidic channel. A variety of nonequilibrium steady states is reported. Under low shear rates, the emulsion is found to exhibit a solidlike behavior, in which cores display a periodic planetarylike motion with approximately equal angular velocity.