Joining European Scientific Forces to Face Pandemics

Despite the international guidelines on the containment of the coronavirus disease 2019 (COVID-19) pandemic, the European scientific community was not sufficiently prepared to coordinate scientific efforts. To improve preparedness for future pandemics, we have initiated a network of nine European-funded Cooperation in Science and Technology (COST) Actions that can help facilitate inter-, multi-, and trans-disciplinary communication and collaboration.

Potential predictors of type-2 diabetes risk: machine learning, synthetic data and wearable health devices

Investigation about the mechanisms involved in the onset of type 2 diabetes in absence of familiarity is the focus of a research project which has led to the development of a computational model that recapitulates the aetiology of the disease. The model simulates the metabolic and immunological alterations related to type-2 diabetes associated to several clinical, physiological and behavioural characteristics of representative virtual patients.

Nonresonant bilinear forms for partially dissipative hyperbolic systems violating the Shizuta-Kawashima condition

We consider a simple example of a partially dissipative hyperbolic system violating the Shizuta-Kawashima condition, ie such that some eigendirections do not exhibit dissipation at all. In the space-time resonances framework introduced by Germain, Masmoudi and Shatah, we prove that, when the source term has a Nonresonant Bilinear Form, as proposed by Pusateri and Shatah CPAM 2013, the formation of singularities is prevented, despite the lack of dissipation. This allows us to show that smooth solutions to this preliminary case-study model exist globally in time.

A genome-wide study on differential methylation in different cancers using TCGA database

Background: DNA methylation is the main epigenetic mechanism driving changes in phenotype without altering genotype. Since the end of the seventies the role of methylation in cancer has become increasingly clear. Objective: The aim of this work is to shed light on the impact of methylation events on cancer cells, providing evidence that differential methylation in small regions, mostly characterized by hypermethylation, affects gene regulation while differential methylation in large genomic regions, mostly characterized by hypomethylation, affects chromosomal organization.