Background: DNA methylation is the main epigenetic mechanism driving changes in phenotype without altering genotype. Since the end of the seventies the role of methylation in cancer has become increasingly clear. Objective: The aim of this work is to shed light on the impact of methylation events on cancer cells, providing evidence that differential methylation in small regions, mostly characterized by hypermethylation, affects gene regulation while differential methylation in large genomic regions, mostly characterized by hypomethylation, affects chromosomal organization.

Background: The aim of a recent research project was the investigation of the mechanisms involved in the onset of type 2 diabetes in the absence of familiarity. This has led to the development of a computational model that recapitulates the aetiology of the disease and simulates the immunological and metabolic alterations linked to type-2 diabetes subjected to clinical, physiological, and behavioural features of prototypical human individuals. Results: We analysed the time course of 46,170 virtual subjects, experiencing different lifestyle conditions.

WeinvestigatethelinearstabilityofshearsneartheCouetteflowforaclassof2Dincompressible stably stratified fluids. Our main result consists of nearly optimal decay rates for perturbations of stationary states whose velocities are monotone shear flows (U (y), 0) and have an exponential density profile. In the case of the Couette flow U(y) = y, we recover the rates predicted by Hartman in 1975, by adopting an explicit point-wise approach in frequency space. As a by-product, this implies optimal decay rates as well as Lyapunov instability in L2 for the vorticity.

In Mobile Unattended Wireless Sensor Networks (MUWSNs), nodes sense the environment and store the acquired data until the arrival of a trusted data sink. MUWSNs, other than being a reference model for an increasing number of military and civilian applications, also capture a few important characteristics of emerging computing paradigms like Participatory Sensing (PS). In this paper, we start by identifying the main features and issues of MUWSNs, revising the related work in the area and highlighting their shortcomings.