Molecular dynamics (MD) has become one of the most powerful tools of investigation in soft matter. Despite such success, simulations of large molecular environments are mostly run using the approximation of closed systems without the possibility of exchange of matter. Due to the molecular complexity of soft matter systems, an optimal simulation strategy would require the application of concurrent multiscale resolution approaches such that each part of a large system can be considered as an open subsystem at a high resolution embedded in a large coarser reservoir of energy and particles.

In the context of network medicine, disease genes, i.e. genes that have been experimentally associated to the onset or progression of a pathology, show a complex set of features that are not easily reduced to, and grasped by a simple network approach (e.g., studying centrality measures or clustering characteristics of the gene network).

The relevant role of freight lorry parking facilities as a tool to reduce nuisances and impact of economic activities in densely populated urban areas is widely recognised in the literature. Nevertheless, the literature currently lacks specific contributions addressing the use of a complex Multiple Criteria Decision Analysis (MCDA) approach for coping with an optimal location of freight lorry parking facilities in the urban context.

Network-based ranking methods (e.g. centrality analysis) have found extensive use in systems medicine for the prediction of essential proteins, for the prioritization of drug targets candidates in the treatment of several pathologies and in biomarker discovery, and for human disease genes identification. Here we propose to use critical nodes as defined by the Critical Node Problem for the analysis of key physiological and pathophysiological signaling pathways, as target candidates for treatment and management of several cancer types, neurologic and inflammatory dysfunctions, among others.

Sex dimorphism in cell response to stress has previously been investigated by different research groups. This dimorphism could be at least in part accounted for by sex-biased expression of regulatory elements such as microRNAs (miRs). In order to spot previously unknown miR expression differences we took advantage of prior knowledge on specialized databases to identify X chromosome-encoded miRs potentially escaping X chromosome inactivation (XCI).

Background. The three terms "panic", "irrationality", and "herding" are ubiquitous in the crowd dynamics literature and have a strong influence on both modelling and management practices. The terms are also commonly shared between the scientific and nonscientific domains. The pervasiveness of the use of these terms is to the point where their underlying assumptions have often been treated as common knowledge by both experts and lay persons. Yet, at the same time, the literature on crowd dynamics presents ample debate, contradiction, and inconsistency on these topics. Method.

Presentazione delle attività di ricerca su computational immunology e network medicine al workshop "Hot Topics in Systems" all'interno della conferenza PLACE2019

Cell motility is crucial to biological functions ranging from wound healing to immune response. The physics of cell crawling on a substrate is by now well understood, whilst cell motion in bulk (cell swimming) is far from being completely characterized. We present here a minimal model for pattern formation within a compressible actomyosin gel, in both 2D and 3D, which shows that contractility leads to the emergence of an actomyosin droplet within a low density background. This droplet then becomes self-motile for sufficiently large motor contractility.

The popularity of the cloud computing paradigm is opening new opportunities for collaborative computing. In this paper we tackle a fundamental problem in open-ended cloud-based distributed computing platforms, i.e., the quest for potential collaborators. We assume that cloud participants are willing to share their computational resources for shared distributed computing problems, but they are not willing to disclose the details of their resources. Lacking such information, we advocate to rely on reputation scores obtained by evaluating the interactions among participants.