IPC - Individualized Paediatric Cure

Un'efficace medicina personalizzata per i tumori pediatrici deve affrontare una moltitudine di sfide, comprese le sfide dominio-specifiche. Per far ciò, il progetto IPC propone un approccio computazionale multicomprensivo, che combina diversi modelli, dall'apprendimento automatico ai modelli meccanicistici, per prevedere terapie standard e sperimentali ottimali per ogni bambino.

AMG4PSBLAS Linear Algebra Package brings Alya one step closer to Exascale

In this work, we interfaced to the Alya code the development version of a software framework for efficient and reliable solution of the sparse linear systems for computation of the pressure field at each time step. We developed a software module in Alya's kernel to interface the current development version of the PSBLAS package (Parallel Sparse Basic Linear Algebra Subroutines) and the sibling package AMG4PSBLAS.

QUALITATIVE ANALYSIS OF DYNAMIC EQUATIONS ON TIME SCALES USING LYAPUNOV FUNCTIONS

We employ Lyapunov functions to study boundedness and stability of dynamic equations on time scales. Most of our Lyapunov functions involve the term |x| and its ?-derivative. In particular, we prove general theorems regarding qualitative analysis of solutions of delay dynamical systems and then use Lyapunov functionals that partially include |x| to provide examples.

A moving boundary problem for reaction and diffusion processes in concrete: Carbonation advancement and carbonation shrinkage

The present work is devoted to modeling and simulation of the carbonation process in concrete. To this aim we introduce some free boundary problems which describe the evolution of calcium carbonate stones under the attack of $ {CO}_2 $ dispersed in the atmosphere, taking into account both the shrinkage of concrete and the influence of humidity on the carbonation process. Indeed, two different regimes are described according to the relative humidity in the environment.

Multi-omics data integration provides insights into the post-harvest biology of a long shelf-life tomato landrace

In this study we investigated the transcriptome and epigenome dynamics of the tomato fruit during post-harvest in a landrace belonging to a group of tomatoes (Solanum lycopersicum L.) collectively known as "Piennolo del Vesuvio", all characterized by a long shelflife. Expression of protein-coding genes and microRNAs as well as DNA methylation patterns and histone modifications were analysed in distinct post-harvest phases. Multi-omics data integration contributed to the elucidation of the molecular mechanisms underlying processes leading to long shelf-life.

Evaluation of HIV-1 integrase variability by combining computational and probabilistic approaches

This study aimed at updating previous data on HIV-1 integrase variability, by using effective bioinformatics methods combining different statistical instruments from simple entropy and mutation rate to more specific approaches such as Hellinger distance. A total of 2133 HIV-1 integrase sequences were analyzed in: i) 1460 samples from drug-naïve [DN] individuals; ii) 386 samples from drug-experienced but INI-naïve [IN] individuals; iii) 287 samples from INI-experienced [IE] individuals.

The FORUM end-to-end simulator project: architecture and results

FORUM (Far-infrared Outgoing Radiation Understanding and Monitoring) will fly as the ninth ESA's Earth Explorer mission, and an end-to-end simulator (E2ES) has been developed as a support tool for the mission selection process and the subsequent development phases. The current status of the FORUM E2ES project is presented together with the characterization of the capabilities of a full physics retrieval code applied to FORUM data.

Comparing home and parcel lockers delivery'systems: a math-heuristic approach

E-commerce is a continuously growing sector worldwide, with important repercussions on the delivery system in urban areas and especially in the Business to Consumer (B2C) sector. The delivery of a package to a consumer's address involves not only high costs for couriers (greater number of kilometres travelled), but also increased congestion and greater environmental pollution (greater volume of pollutants released into the air).