Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation
Two T helper (Th) cell subsets, namely Th1 and Th2 cells, play an important role in inflammatory diseases. The two subsets
are thought to counter-regulate each other, and alterations in their balance result in different diseases. This paradigm has
been challenged by recent clinical and experimental data. Because of the large number of genes involved in regulating Th1
and Th2 cells, assessment of this paradigm by modeling or experiments is difficult. Novel algorithms based on formal
methods now permit the analysis of large gene regulatory networks.