Growth Arrest-Specific Transcript 5 associated snoRNA levels are related to p53 expression and DNA damage in colorectal cancer
Background: The growth arrest-specific transcript 5 gene (GAS5) encodes a long noncoding RNA (lncRNA) and hosts a number of small nucleolar RNAs (snoRNAs) that have recently been implicated in multiple cellular processes and cancer. Here, we investigate the relationship between DNA damage, p53, and the GAS5 snoRNAs to gain further insight into the potential role of this locus in cell survival and oncogenesis both in vivo and in vitro.
AnaLysis of Expression on human chromosome 21, ALE-HSA21: a pilot integrated web resource
Transcriptome studies have shown the pervasive nature of transcription, demonstrating almost all the genes undergo alternative splicing. Accurately annotating all transcripts of a gene is crucial. It is needed to understand the impact of mutations on phenotypes, to shed light on genetic and epigenetic regulation of mRNAs and more generally to widen our knowledge about cell functionality and tissue diversity.
Understanding gene regulatory mechanisms by integrating ChIP-seq and RNA-seq data: statistical solutions to biological problems.
The availability of omic data produced from international consortia, as well as from worldwide laboratories, is offering the possibility both to answer long-standing questions in biomedicine/molecular biology and to formulate novel hypotheses to test. However, the impact of such data is not fully exploited due to a limited availability of multi-omic data integration tools and methods. In this paper, we discuss the interplay between gene expression and epigenetic markers/transcription factors. We show how integrating ChIP-seq and RNA-seq data can help to elucidate gene regulatory mechanisms.
On an inverse problem for scalar conservation laws
We study in what sense one can determine the flux functions k = k(x) and f = f(u), k piecewise constant, in the scalar hyperbolic conservation law u(t) + (k(x)f (u))(x) = 0 by observing the solution u(t, center dot) of the Cauchy problem with suitable piecewise constant initial data u vertical bar(t=0) = u(o).
Linear-quadratic N-person and mean-field games with ergodic cost
We consider stochastic differential games with N players, linear-Gaussian dynamics in arbitrary state-space dimension, and long-time-average cost with quadratic running cost. Admissible controls are feedbacks for which the system is ergodic. We first study the existence of affine Nash equilibria by means of an associated system of N Hamilton-Jacobi-Bellman (HJB) and N Kolmogorov-Fokker-Planck (KFP) partial differential equations.
