Background: Mutations of the mitochondrial protein paraplegin cause hereditary spastic paraplegia type 7 (SPG7), a so-far untreatable degenerative disease of the upper motoneuron with still undefined pathomechanism. The intermittent mitochondrial permeability transition pore (mPTP) opening, called flickering, is an essential process that operates to maintain mitochondrial homeostasis by reducing intra-matrix Ca and reactive oxygen species (ROS) concentration, and is critical for efficient synaptic function.

Visibility has an encompassing importance in humans' perception of the landscape, since the first encounter with a new environment normally occurs through sight. In historical and archaeological studies, two main methods (i.e., the geometric method and the Geographical Information System [GIS] computation) have been employed to determine the distance from which an object can be recognized. However, neither is exhaustive when applied to a maritime context, where the main factor affecting the visibility radius is weather.

The main focus of this paper is the characterization and exploitation of the asymptotic spectrum of the saddle--point matrix sequences arising from the discretization of optimization problems constrained by elliptic partial differential equations. They uncover the existence of an hidden structure in these matrix sequences, namely, they show that these are indeed an example of Generalized Locally Toeplitz (GLT) sequences.

MIPAS is a Fourier Transform spectrometer that measured the atmospheric limb emission spectra in the middle infrared on board the ENVISAT satellite.

We consider an empirical Bayes approach to standard nonparametric regression estimation using a nonlinear wavelet methodology. Instead of specifying a single prior distribution on the parameter space of wavelet coefficients, which is usually the case in the existing literature, we elicit the epsilon-contamination class of prior distributions that is particularly attractive to work with when one seeks robust priors in Bayesian analysis.

Recent years have witnessed a massive push towards reproducible research in neuroscience. Unfortunately, this endeavor is often challenged by the large diversity of tools used, project-specific custom code and the difficulty to track all user-defined parameters. NeuroPycon is an open-source multi-modal brain data analysis toolkit which provides Python-based template pipelines for advanced multi-processing of MEG, EEG, functional and anatomical MRI data, with a focus on connectivity and graph theoretical analyses.

The dynamics of active colloids is very sensitive to the presence of boundaries and interfaces which therefore can be used to control their motion. Here we analyze the dynamics of active colloids adsorbed at a fluid-fluid interface. By using a mesoscopic numerical approach which relies on an approximated numerical solution of the Navier-Stokes equation, we show that when adsorbed at a fluid interface, an active colloid experiences a net torque even in the absence of a viscosity contrast between the two adjacent fluids.

This article is concerned with the analysis of the one-dimensional compressible Euler equations with a singular pressure law, the so-called hard sphere equation of state. The result is twofold. First, we establish the existence of bounded weak solutions by means of a viscous regularization and refined compensated compactness arguments. Second, we investigate the smooth setting by providing a de- tailed description of the impact of the singular pressure on the breakdown of the solutions.