Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on 5-bromo-2'-deoxyuridine incorporation in spleen, lymph nodes, and bone marrow
To study naive and memory CD8 T cell turnover, we performed BrdU incorporation experiments in adult thymectomized C57BL/6 mice and analyzed data in a mathematical framework.
Genetic algorithms in bus network optimisation
This paper focuses on a new method to compute fitness function (ff) values in genetic algorithms for bus network optimization. In the proposed methodology, a genetic algorithm is used to generate iteratively new populations (sets of bus networks). Each member of the population is evaluated by computing a number of performance indicators obtained by the analysis of the assignment of the O/D demand associated to the considered networks. Thus, ff values are computed by means of a multicriteria analysis executed on the performance indicators so found.
