Storia dei maggiori progetti sviluppati da Mauro Picone per costruire in Italia un calcolatore elettronico prima della CEP. A questi progetti segue la collaborazione allo sviluppo della CEP tramite la realizzazione di un simulatore della calcolatrice pisana sulla Ferranti Mark 1* dell'INAC (FINAC). Invine, si accenna alla collaborazione con Olivetti per realizzare la serie ELEA 9004.

In this paper, the lab-on-chip section for a protein assay is designed and optimized. To avoid severe reliability problems related to activated surface stability, a dynamic assay approach is adopted: protein-to-protein neutralization is performed while proteins diffuse freely in the reaction chamber. The related refraction index change is detected via an integrated interferometer. The structure is also design to provide a functional test of the reference protein solution, which is generally required for qualification for medical uses.

We introduce a numerical scheme to approximate a quasilinear hyperbolic system which models the movement of cells under the influence of chemotaxis. Since we expect to find solutions which contain vacuum parts, we propose an upwinding scheme which properly handles the presence of vacuum and which gives a good approximation of the time asymptotic states of the system. For this scheme we prove some basic analytical properties and study its stability near some of the steady states of the system.