Design and Optimization of Reaction Chamber and Detection System in Dynamic Labs-on-Chip for Proteins Detection

Abstract
In this paper, the lab-on-chip section for a protein assay is designed and optimized. To avoid severe reliability problems related to activated surface stability, a dynamic assay approach is adopted: protein-to-protein neutralization is performed while proteins diffuse freely in the reaction chamber. The related refraction index change is detected via an integrated interferometer. The structure is also design to provide a functional test of the reference protein solution, which is generally required for qualification for medical uses.
Anno
2013
Tipo pubblicazione
Altri Autori
M. Briani, G. Germani, E. Iannone, M. Moroni, R. Natalini
Editore
Institute of Electrical and Electronics Engineers,
Rivista
IEEE transactions on biomedical engineering (Print)