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The highly conserved zinc finger CCCTC-binding factor (CTCF) regulates genomic imprinting and gene expression by acting as a transcriptional activator or repressor of promoters and insulator of enhancers. The multiple functions of CTCF are accomplished by co-association with other protein partners… |
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Indefinite symmetric matrices occur in many applications, such as optimization, least squares problems, partial differential equations, and variational problems. In these applications one is often interested in computing a factorization of the indefinite matrix that puts into evidence the inertia… |
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General relativity considers Dixons theory as the standard theory to deal
with the motion of extended bodies in a given gravitational background. We discuss
here the features of the reaction of an extended body to the passage of a weak
gravitational wave. We find that the body acquires a dipolar… |
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Purpose: We studied microRNAs as potential biomarkers for Pompe disease. Methods: We analyzed microRNA expression by small RNA-seq in tissues from the disease murine model at two different ages (3 and 9 months), and in plasma from Pompe patients. Results: In the mouse model we found 211 microRNAs… |
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Background: The growth arrest-specific transcript 5 gene (GAS5) encodes a long noncoding RNA (lncRNA) and hosts a number of small nucleolar RNAs (snoRNAs) that have recently been implicated in multiple cellular processes and cancer. Here, we investigate the relationship between DNA damage, p53, and… |
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Standard reaction-diffusion systems are characterized by infinite velocities and no persistence in the movement of individuals, two conditions that are violated when considering living organisms. Here we consider a discrete particle model in which individuals move following a persistent random walk… |
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Given a simple undirected graph G and a positive integer s, the maximum vertex coverage problem (MVC) is the problem of finding a set U of s vertices of G such that the number of edges having at least one endpoint in U is as large as possible. The problem is NP-hard even in bipartite graphs, as… |
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We investigate how the Z-type dynamic approach can be applied to control backward bifurcation phenomena in epidemic models. Because of its rich phenomenology, that includes stationary or oscillatory subcritical persistence of the disease, we consider the SIR model introduced by Zhou & Fan in [… |
