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Background and Objective: The paper focuses on the numerical strategies to optimize a plasmid DNA delivery protocol, which combines hyaluronidase and electroporation. Methods: A well-defined continuum mechanics model of muscle porosity and advanced numerical optimization strategies have been used,… |
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It is observed in vitro and in vivo that when two populations of different types of cells come near to each other, the rate of proliferation of most cells decreases. This phenomenon is often called contact inhibition of growth between two cells. In this paper, we consider a simplified 1-dimensional… |
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We consider stochastic differential games with N nearly identical players, linear-Gaussian dynamics, and infinite horizon discounted quadratic cost. Admissible controls are feedbacks for which the system is ergodic. We first study the existence of affine Nash equilibria by means of an associated… |
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The aim of this paper is to prove the strong convergence of the solutions to a vector-BGK model under the diffusive scaling to the incompressible Navier-Stokes equations on the two-dimensional torus. This result holds in any interval of time [0,T], with T>0. We also provide the global in time… |
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We provide large deviationsprinciple for Poisson shot noise processes, under heavy tail semiexponential conditions |
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Simulated data are crucial for evaluating epistasis detection tools in genome-wide association studies. Existing simulators are limited, as they do not account for linkage disequilibrium (LD), support limited interaction models of single nucleotide polymorphisms (SNPs) and only dichotomous… |
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Human blood flow is a multiscale problem: in first approximation, blood is a dense suspension of plasma and deformable red cells. Physiological vessel diameters range from about one to thousands of cell radii. Current computational models either involve a homogeneous fluid and cannot track… |
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We introduce non-local dynamics on directed networks through the construction of a fractional version of a non-symmetric Laplacian for weighted directed graphs. Furthermore, we provide an analytic treatment of fractional dynamics for both directed and undirected graphs, showing the possibility of… |
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