Articolo in rivista

Estimation of a new stochastic transform for solving the complex exponentials approximation problem: computational aspects and applications

Many real life problems can he reduced to the solution of a complex exponentials approximation problem which is usually ill-posed. Recently a new transform for solving this problem, formulated as a specific moments problem in the plane, has been proposed in a theoretical framework. In this work…

Handling obstacles in pedestrian simulations: Models and optimization

In this paper we are concerned with the simulation of crowds in built environments, where obstacles play a role in the dynamics and in the interactions among pedestrians. First of all, we review the state-of-the-art of the techniques for handling obstacles in numerical simulations. Then, we…

Multi-Kepler GPU vs. multi-Intel MIC for spin systems simulations

We present and compare the performances of two many-core architectures: the Nvidia Kepler and the Intel MIC both in a single system and in cluster configuration for the simulation of spin systems. As a benchmark we consider the time required to update a single spin of the 3D Heisenberg spin glass…

Characterization of the Shells in Layer-By-Layer Nanofunctionalized Particles: A Computational Study

Drug delivery carriers are considered an encouraging approach for the localized treatment of disease with minimum effect on the surrounding tissue. Particularly, layer-by-layer releasing particles have gained increasing interest for their ability to develop multifunctional systems able to control…

Analysis and short-time extrapolation of stock market indexes through projection onto discrete wavelet subspaces

We consider the problem of short-time extrapolation of blue chips' stocks indexes in the context of wavelet subspaces following the theory proposed by X.-G. Xia and co-workers in a series of papers \cite{XLK,XKZ,LK,LXK}. The idea is first to approximate the oscillations of the corresponding stock…

A fluid dynamics multidimensional model of biofilm growth: stability, influence of environment and sensitivity

In this article, we study in detail the fluid dynamics system proposed in Clarelli et al. (2013, J. Math. Biol., 66, 1387-1408) to model the formation of cyanobacteria biofilms. After analysing the linear stability of the unique non-trivial equilibrium of the system, we introduce in the model the…

Human models of aging and longevity

Background: The aging phenotype in humans is very heterogeneous and can be described as a complex mosaic resulting from the interaction of a variety of environmental, stochastic and genetic-epigenetic variables. Therefore, each old person must be considered as a singleton, and consequently the…

Beyond classical consensus clustering: the Least Squares approach to multiple solutions

Clustering is one of the most important unsupervised learning problems and it consists of finding a common structure in a collection of unlabeled data. However, due to the ill-posed nature of the problem, different runs of the same clustering algorithm applied to the same data-set usually produce…

Distinct Antigen Delivery Systems Induce Dendritic Cells' Divergent Transcriptional Response: New Insights from a Comparative and Reproducible Computational Analysis.

Vaccination is the most successful and cost-effective method to prevent infectious diseases. However, many vaccine antigens have poor in vivo immunogenic potential and need adjuvants to enhance immune response. The application of systems biology to immunity and vaccinology has yielded crucial…

Convergence in probability of the Mallows and GCV wavelet and Fourier regularization methods

Wavelet and Fourier regularization methods are effective for the nonparametric regression problem. We prove that the loss function evaluated for the regularization parameter chosen through GCV or Mallows criteria is asymptotically equivalent in probability to its minimum over the regularization…