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Methylage is an epigenetic marker of biological age that exploits the correlation between the methylation state of specific CG dinucleotides (CpGs) and chronological age (in years), gestational age (in weeks), cellular age (in cell cycles or as telomere length, in kilobases). Using DNA methylation… |
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We consider an initial-boundary value problem for a degenerate pseudoparabolic regularization of a nonlinear forward-backward-forward parabolic equation, with a bounded nonlinearity which is increasing at infinity. We prove existence of suitably defined nonnegative solutions of the problem in a… |
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The statistical properties of fluid particles transported by a three-dimensional fully developed turbulent flow are investigated by means of high resolution direct numerical simulations. Single trajectory statistics are investigated in a time range spanning more than three decades, from less than a… |
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The algebraically special frequencies of Taub-NUT black hole are investigated in detail in comparison with the known results concerning the case of Schwarzschild.
The periodicity of the time coordinate, required for regularity of the solution, prevents algebraically special frequencies to be… |
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Skin lesion segmentation is one of the crucial steps for an efficient non-invasive computer-aided early diagnosis of melanoma. This paper investigates how to use colour information, besides saliency, for determining the pigmented lesion region automatically. Unlike most existing segmentation… |
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We prove a dimension-invariant imbedding estimate for Sobolev spaces of first order into a small Lebesgue space, and we establish the optimality of its fundamental function. Namely, for any 1 < p < ?, the inequality with a constant c_p, related to the imbedding of W_0^{1,p}(B_n) into Y_p(0,1… |
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We present a mesoscopic lattice model for non-ideal fluid flows with directional interactions, mimicking the effects of hydrogen bonds in water. The model supports a rich and complex structural dynamics of the orientational order parameter, and exhibits the formation of disordered domains whose… |
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Using computer simulations, the finite sample performance of a number of classical and Bayesian wavelet shrinkage estimators for Poisson counts is examined. For the purpose of comparison, a variety of intensity functions, background intensity levels, sample sizes, primary resolution levels, wavelet… |
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We generalize the nonstandard Euler and Heun schemes in order to provide explicit geometric numerical integrators for biochemical systems, here denoted as GeCo schemes, that preserve both positivity of the solutions and linear invariants. We relax the request on the order convergence of the… |
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The human retina is a specialized tissue involved in light stimulus transduction. Despite its unique biology, an accurate reference transcriptome is still missing. Here, we performed gene expression analysis (RNA-seq) of 50 retinal samples from non-visually impaired post-mortem donors. We… |
