Epigenetic modifications are correlated to environmental factors. Exposure to ambient air pollution may contribute to the development of different diseases such as cancer, cardiovascular diseases, and neurological and metabolic disorders. Looking for the association between DNA methylation and exposure biomarkers may help in the prevention of adverse effects. Association analysis can be carried out through regression modeling.

CRC is an adult-onset carcinoma representing the third most common cancer and the second leading cause of cancer-related deaths in the world. EO-CRC (<45 years of age) accounts for 5% of the CRC cases and is associated with cancer-predisposing genetic factors in half of them. Here, we describe the case of a woman affected by BWSp who developed EO-CRC at age 27. To look for a possible molecular link between BWSp and EO-CRC, we analysed her whole-genome genetic and epigenetic profiles in blood, and peri-neoplastic and neoplastic colon tissues.

first_pagesettingsOrder Article Reprints Open AccessArticle ICF1-Syndrome-Associated DNMT3B Mutations Prevent De Novo Methylation at a Subset of Imprinted Loci during iPSC Reprogramming by Ankit Verma 1,2,+ORCID,Varsha Poondi Krishnan 2,+ORCID,Francesco Cecere 1ORCID,Emilia D'Angelo 1ORCID,Vincenzo Lullo 2ORCID,Maria Strazzullo 2ORCID,Sara Selig 3,4ORCID,Claudia Angelini 5ORCID,Maria R.