The "Istituto per le Applicazioni del Calcolo" M. Picone (IAC) is a major Research Institute in Applied Mathematics of the . Its history goes back to 1927 when it was founded by Mauro Picone.
In 2002 it was completely renewed, with four locations in Rome, Bari, Florence and Naples.
Its mission is to develop highly advanced mathematical, statistical and computational methods in order to solve, in a mostly interdisciplinary context, problems with strong relevance to society and industry. The scientific staff consists of about 55 researchers.

The main research activities are synthetized in the following list of keywords, which reflects an equilibrium between the development of advanced mathematical methods, their applications often of interdisciplinary character, and computational aspects:

partial differential equations, statistics, computer science, operational research, inverse problems, signal and image processing, mathematical physics, relativity theory, numerical analysis, computational linear algebra, fluid mechanics, complex systems, biomedical and industrial applications, cultural heritage, mathematical finance, data analysis, variational methods, optimization, control theory, computer graphics and scientific visualization, theory of computation, high performance computation, numerical, symbolic and statistical computing.