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Background: Sequencing technologies applied to mammals' microbiomes have revolutionized our understanding of health and disease. Hence, to assess diseases' progression as well as therapies longterm effects, the impact of maladies and drugs on the gut-intestinal (GI) microbiome has to be evaluated.… |
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Changes in blood epigenetic age have been associated with several pathological conditions and have recently been described to anticipate cancer development. In this work, we analyze a publicly available leukocytes methylation dataset to evaluate the relation between DNA methylation age and the… |
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This paper presents a new hybrid approach integrating the cross-entropy (CE) algorithm and the sequential quadratic programming (SQP) technique to solve the economic load dispatch (ELD) problem related to electrical power generating units. Due to the introduction of the valve-point effect in the… |
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The reverse mortgage market has been expanding rapidly in developed economies in recent years. Reverse mortgages provide an alternative source of funding for retirement income and health care costs. Increase in life expectancies and decrease in the real income at retirement continue to worry those… |
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This paper focuses on assessing the financial position of an insurer issuing a portfolio of Variable Annuities (VAs). Two multivariate models for the underlying and the interest rate are considered. The first model uses a single total rate of return for the basket of assets. The second one, jointly… |
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We show in this paper that the roots $x_1$ and $x_2$ of a scalar quadratic polynomial $ax^2 + bx + c = 0$
with real or complex coefficients $a, b, c$ can be computed in an element-wise mixed stable manner, measured in
a relative sense. We also show that this is a stronger property than norm-wise… |
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Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines… |
