Articolo in rivista

Modelling mass diffusion for a multi-layer sphere immersed in a semi-infinite medium: application to drug delivery

We present a general mechanistic model of mass diffusion for a composite sphere placed in a large ambient medium. The multi-layer problem is described by a system of diffusion equations coupled via interlayer boundary conditions such as those imposing a finite mass resistance at the extemal surface…

Fixed point iterations for a class of nonstandard Sturm -Liouville boundary value problems

The paper examines a particular class of nonlinear integro-differential equations consisting of a Sturm-Liouville boundary value problem on the half-line, where the coefficient of the differential term depends on the unknown function by means of a scalar integral operator. In order to handle the…

Determination of the optimal therapeutic protocol in cancer immunotherapy

Cancer immunotherapy aims at eliciting an immune system response against the tumor. However, it is often characterized by toxic side-effects. Limiting the tumor growth and, concurrently, avoiding the toxicity of a drug, is the problem of protocol design. We formulate this question as an…

A rare mutation model in a spatial heterogeneous environment

We propose a stochastic model in evolutionary game theory where individuals (or subpopulations) can mutate changing their strategies randomly (but rarely) and explore the external environment. This environment affects the selective pressure by modifying the payoff arising from the interactions…

Cumulative compressibility effects on slow reactive dynamics in turbulent flows

Reactions in turbulent flows, chemical reactions or combustion, are common. Typically reaction time scales are much shorter than turbulence timescales. In biological applications, as it is the case for bacterial and plankton populations living under the influence of currents in oceans and lakes,…

Comparison estimates in anisotropic variational problems

A pointwise inequality between the radially decreasing symmetrals of minimizers of (possibly) anisotropic variational problems and the minimizers of suitably symmetrized problems is established. As a consequence, a priori sharp estimates for norms of the relevant minimizers are derived.

A stochastic model for interacting neurons in the olfactory bulb

We focus on interacting neurons organized in a block-layered network devoted to the information processing from the sensory system to the brain. Specifically, we consider the firing activity of olfactory sensory neurons, periglomerular, granule and mitral cells in the context of the neuronal…

Epidemic reaction-diffusion system with cross-diffusion: modeling and numerical solution

Reaction-diffusion systems with cross-diffusion are analyzed here for modeling the population dynamics of epidemic systems. In this paper specific attention is devoted to the numerical analysis and simulation of such systems to show that, far from possible pathologies, the qualitative behaviour of…

Multi-relaxation time Lattice Boltzmann Model for multiphase flows,

Fully anisotropic elliptic problems with minimally integrable data

We investigate nonlinear elliptic Dirichlet problems whose growth is driven by a general anisotropic N-function, which is not necessarily of power-type and need not satisfy the ? nor the ? -condition. Fully anisotropic, non-reflexive Orlicz-Sobolev spaces provide a natural functional framework…