Abstract
Degeneration is a hallmark of autoimmune diseases, whose incidence grows worldwide. Current
therapies attempt to control the immune response to limit degeneration, commonly promoting
immunodepression. Differently, mechanical stimulation is known to trigger healing (regeneration) and
it has recently been proposed locally for its therapeutic potential on severely injured areas. As the early
stages of healing consist of altered intra- and inter-cellular fluxes of soluble molecules, we explored the
potential of this early signal to spread, over time, beyond the stimulation district and become systemic,
to impact on distributed or otherwise unreachable injured areas. We report in a model of arthritis in
rats how stimulations delivered in the subcutaneous dorsal tissue result, over time, in the control and
healing of the degeneration of the paws' joints, concomitantly with the systemic activation of wound
healing phenomena in blood and in correlation with a more eubiotic microbiome in the gut intestinal
district.
Anno
2017
Autori IAC
Tipo pubblicazione
Altri Autori
Nardini, Christine; Devescovi, Valentina; Liu, Yuanhua; Zhou, Xiaoyuan; Lu, Youtao; Dent, Jennifer E.
Editore
Nature Publishing Group
Rivista
Scientific reports (Nature Publishing Group)