Abstract
Background: The optimal stage for initiating antiretroviral therapies in HIV-1 bearing patients is
still a matter of debate.
Methods: We present computer simulations of HIV-1 infection aimed at identifying the pro et
contra of immediate as compared to deferred Highly Active Antiretroviral Therapy (HAART).
Results: Our simulations highlight that a prompt specific CD8+ cytotoxic T lymphocytes response
is detected when therapy is delayed. Compared to very early initiation of HAART, in deferred
treated patients CD8+ T cells manage to mediate the decline of viremia in a shorter time and, at
interruption of therapy, the virus experiences a stronger immune pressure. We also observe,
however, that the immunological effects of the therapy fade with time in both therapeutic regimens.
Thus, within one year from discontinuation, viral burden recovers to the value at which it would
level off in the absence of therapy.
In summary, simulations show that immediate therapy does not prolong the disease-free period
and does not confer a survival benefit when compared to treatment started during the chronic
infection phase.
Conclusion: Our conclusion is that, since there is no therapy to date that guarantees life-long
protection, deferral of therapy should be preferred in order to minimize the risk of adverse effects,
the occurrence of drug resistances and the costs of treatment.
Anno
2009
Autori IAC
Tipo pubblicazione
Altri Autori
Paci P., Carello R., Bernaschi M., D;Offizi G., Castiglione F.
Editore
BioMed Central,
Rivista
BMC infectious diseases (Online)