Abstract
More than twenty years ago the reverse vaccinology paradigm came to light trying to
design new vaccines based on the analysis of genomic information in order to select
those pathogen peptides able to trigger an immune response. In this context, focusing
on the proteome of Trypanosoma cruzi, we investigated the link between the
probabilities for pathogen peptides to be presented on a cell surface and their distance
from human self. We found a reasonable but, as far as we know, undiscovered
property: the farther the distance between a peptide and the human-self the higher
the probability for that peptide to be presented on a cell surface. We also found that
the most distant peptides from human self bind, on average, a broader collection of
HLAs than expected, implying a potential immunological role in a large portion of
individuals. Finally, introducing a novel quantitative indicator for a peptide to
measure its potential immunological role, we proposed a pool of peptides that could be
potential epitopes and that can be suitable for experimental testing. The software to
compute peptide classes according to the distance from human self is free available at
http://www.iasi.cnr.it/~dsantoni/nullomers.
Anno
2020
Autori IAC
Tipo pubblicazione
Altri Autori
Davide Vergni , Rosanna Gaudio , Daniele Santoni
Editore
Public Library of Science
Rivista
PloS one