Abstract
Implantation of drug eluting stents following percutaneous trans-
luminal angioplasty has revealed a well established technique for treating occlusions caused by the atherosclerotic plaque. However, due to the risk of vascular
re-occlusion, other alternative therapeutic strategies of drug delivery are currently being investigated. Polymeric endoluminal pave stenting is an emerging
technology for preventing blood erosion and for optimizing drug release. The
classical and novel methodologies are compared through a mathematical model
able to predict the evolution of the drug concentration in a cross-section of the
wall. Though limited to an idealized configuration, the present model is shown
to catch most of the relevant aspects of the drug dynamics in a delivery system. Results of numerical simulations shows that a bi-layer gel paved stenting
guarantees a uniform drug elution and a prolonged perfusion of the tissues,
and remains a promising and effective technique in drug delivery.
Anno
2009
Autori IAC
Tipo pubblicazione
Altri Autori
Grassi M.; Pontrelli G.; Teresi L.; Grassi G.; Comel L.; Ferluga A.; Galasso L.
Editore
American Institute of Mathematical Sciences,
Rivista
Mathematical biosciences and engineering