Abstract
An analytical solution for solving the transient drug diffusion in adjoining porous wall layers faced with a
drug-eluting stent is presented. The endothelium, intima, internal elastic lamina and media are all treated
as homogeneous porous media and the drug transfer through them is modelled by a set of coupled partial
differential equations. The classical separation of variables method for a multi-layer configuration is used.
The model addresses the concept of penetration depth for multi-layer solids that is useful to treat the
wall thickness by estimating a physical bound for mass diffusion. Drug concentration level and mass profiles in each layer at various times are given and discussed.
Anno
2010
Autori IAC
Tipo pubblicazione
Altri Autori
Pontrelli G.; de Monte F.
Editore
Pergamon Press.
Rivista
International Journal of Heat and Mass Transf. (Print)