Abstract
We present a multi-layer mathematical model to describe the transdermal drug release from an iontophoretic system. The Nernst-Planck equation describes the basic convection-diffusion process, with the electric potential obtained by solving the Laplace's equation. These equations are complemented with suitable interface and boundary conditions in a multi-domain. The stability of the mathematical problem is discussed in different scenarios and a finite-difference method is used to solve the coupled system. Numerical experiments are included to illustrate the drug dynamics under different conditions.
Anno
2017
Autori IAC
Tipo pubblicazione
Altri Autori
Pontrelli, Giuseppe; Lauricella, Marco; Ferreira, Jose A; Pena, Goncalo
Editore
Oxford University Press.
Rivista
Mathematical medicine and biology (Online)